Crystal Structure and DNA Binding Properties of A Sulfide Bridged Dimeric Schiff Base Compound

Authors : Mustafa BAL, Ayşegül KÖSE

Pages : 818-831

Doi:10.47495/okufbed.1180912

View : 9 | Download : 5

Publication Date : 2023-03-10

Article Type : Research Paper

Abstract :In this research, a novel 4,4\`-Diaminodiphenyl sulfide-based Schiff base compound [6,6\`-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(1E,1\`E);-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(thiobis insert ignore into journalissuearticles values(4,1-phenylene);); bisinsert ignore into journalissuearticles values(azaneylylidene);); bisinsert ignore into journalissuearticles values(methaneylylidene);); bisinsert ignore into journalissuearticles values(3-insert ignore into journalissuearticles values(diethylamino); phenol); insert ignore into journalissuearticles values(A);], which is known to have good biological activity and forms the basis of anticancer drugs, was successfully synthesized. Structural characterization of the synthesized Schiff base compound was determined by FT-IR and 1H-13C NMR, spectroscopies. Also, the molecular structure of the compound was determined by a single-crystal X-ray diffraction study. The DNA binding ability of the compound was measured using UV-vis spectroscopy. Using the spectral changes, the DNA binding constant of the compound was calculated as Kb insert ignore into journalissuearticles values(M-1);= 6.25x105. The Kb value found suggests the existence of an intercalative interaction.
Keywords : Schiff Bases, DNA binding, X ray diffraction, Drugs, Schiff Bases, DNA binding, X ray diffraction, Drugs