Using small size grafts in live donor liver transplantation: is size important?

Authors : Eryigit EREN, Ayhan DİNÇKAN

Pages : 412-419

Doi:10.31362/patd.1265140

View : 45 | Download : 71

Publication Date : 2023-07-01

Article Type : Research Paper

Abstract :Purpose: In living donor liver transplantation, it is preferred that the ratio of the weight of the graft to the weight of the recipient insert ignore into journalissuearticles values(GRWR); be higher than 0.8%. We aimed to compare recipients with a GRWR greater than 0.8% and those with a small GRWR regarding post-transplant complications and outcomes. Materials and methods: Data of the patients who had undergone living donor liver transplant surgery in İstinye University Hospital Liver Transplant Unit between January 2017 and July 2022 were reviewed. The study group patients were classified as GRWR<0.8% insert ignore into journalissuearticles values(Group 1);, GRWR 0.8-1% insert ignore into journalissuearticles values(Group 2);, and GRWR>1% insert ignore into journalissuearticles values(Group 3); and compared regarding clinical data, complications, and mortality rates. Results: Liver transplant recipients from 220 living donors were included. The mean recipient age was 53.6 insert ignore into journalissuearticles values(18-79);. The comparative analysis between Group 1 insert ignore into journalissuearticles values(n=29);, Group 2 insert ignore into journalissuearticles values(n=70);, and Group 3 insert ignore into journalissuearticles values(n=121); revealed significant differences concerning the rates of bile leak and the length of hospital stay insert ignore into journalissuearticles values(p=0.033, p<0.05);. Bile leak rates were 7.4% in Group 1, 6% in Group 2, and 0.8% in Group 3. The bile leakage rate was significantly lower in Group 3 than in Groups 1 and 2 insert ignore into journalissuearticles values(p=0.041, p<0.05);. The medians of hospitalization periods were 18 insert ignore into journalissuearticles values(7-40); days, 15 insert ignore into journalissuearticles values(5-46); days, and 16 insert ignore into journalissuearticles values(1-130); days in groups 1, 2, and 3. In addition, the median length of stay was higher in Group 1 than in groups 2 and 3 insert ignore into journalissuearticles values(p=0.033);. In terms of other parameters, the three groups gave similar results. Conclusion: Although a GRWR value of lower than 0.8 seems as a factor causing prolonged hospital stay, and a GRWR value of higher than 1 seems to lower the risk of biliary complications after a live donor liver transplantation, these changes are not associated with the changes in total complication and acute rejection rates and patient survival.
Keywords : Greft alıcı ağırlık oranı, karaciğer nakli, canlı vericili