Histopathologic features of inflammatory fibroid polyps and risk of cancer development: a case series

Authors : Erdem ÇOMUT, Yeliz ARMAN KARAKAYA, Mustafa ÇELİK, Neşe DEMİRKAN

Pages : 476-485

Doi:10.31362/patd.1270475

View : 24 | Download : 49

Publication Date : 2023-07-01

Article Type : Research Paper

Abstract :Purpose: Inflammatory fibroid polyp insert ignore into journalissuearticles values(IFP); is seen in the gastrointestinal tract. In most cases, somatic mutations in PDGFRA gene were observed and the true neoplastic origin of this entity was understood. It is a benign mesenchymal tumor and rarely recurs. The aim of the study was to reveal the histopathologic features of our IFP cases and to investigate the risk of cancer in one case. Materials and methods: We performed a retrospective clinicopathological analysis of patients insert ignore into journalissuearticles values(n=12); who were reported as IFP between 2012 and 2022. Formalin-fixed, paraffin-embedded and hematoxylin-eosin insert ignore into journalissuearticles values(H&E);- stained slides of the cases were re-examined by two pathologists microscopically. Results: All patients were adults and ranged in age from 30 to 85. Male to female ratio was 1:2. One polyp was localized in small intestine, one in colon, and the others in stomach. Histologically, there were hyperplastic epithelial changes insert ignore into journalissuearticles values(7/12);, low-grade insert ignore into journalissuearticles values(3/12);, and high-grade dysplasia insert ignore into journalissuearticles values(1/12); accompanying IFPs. One case was associated with early gastric adenocarcinoma. Discussion: Although IFP appears as a benign mesenchymal tumor, it should be kept in mind that dysplasia and rarely carcinoma may accompany this lesion. Larger case series are needed to elucidate the mechanisms of dysplasia and carcinoma development associated with IFP.
Keywords : İnflamatuar fibroid polip, gastrointestinal, displazi, karsinom, histopatoloji