Association between vascular calcification, atherosclerosis and inflammatory markers in end-stage renal disease patient and simple method for detecting vascular calcification (direct radiography)

Authors : Rüya MUTLUAY, Çiğdem MENGÜŞ, Neslihan TEZCAN, Emel ISIKTAS SAYILAR, Ulver DERICI, Ceyla KONCA DEĞERTEKİN, Serap GÜLTEKİN, Sevim GÖNEN, Gülten TAÇOY

Pages : 558-569

Doi:10.31362/patd.1274511

View : 91 | Download : 118

Publication Date : 2023-10-01

Article Type : Research Paper

Abstract :Purpose: In our study, we planned to investigate the relationship of malnutrition with inflammation, atherosclerosis and calcification in dialysis patients. Materials and methods: 140 Chronic kidney disease insert ignore into journalissuearticles values(CKD); patients and 44 healthy controls were included in the study. Carotid artery intima-media thickness insert ignore into journalissuearticles values(CIMT); was measured by doppler ultrasonography. Valvular calcification was assessed by echocardiography and vascular calcification scores insert ignore into journalissuearticles values(VCS); were done based on the radiograms. Biochemical parameters were assessed using routine laboratory methods. Subjective global assessment insert ignore into journalissuearticles values(SGA); was used to evaluate malnutrition. Results: In the study, VCS showed no differences between hemodialysis insert ignore into journalissuearticles values(HD); and peritoneal dialysis insert ignore into journalissuearticles values(PD); patients insert ignore into journalissuearticles values(1.84±2.35 for HD, 1.77±1.64 for PD; p=0.83);. CIMT, Osteopontin insert ignore into journalissuearticles values(OPN);, interleukin-6 insert ignore into journalissuearticles values(IL-6); and homocysteine were significantly different in both dialysis groups compared to healthy controls. The Mean carotid intima-media thickness insert ignore into journalissuearticles values(m-CIMT); was higher in HD patients compared to PD group. CIMT, vascular calcification and SGA scores showed positive correlation with age, dialysis duration and valvular calcification grades, and negative correlation with albumin levels. A positive correlation between SGA scores and high-sensitive C-reactive protein insert ignore into journalissuearticles values(hs-CRP); levels was also noted. On multiple regression analysis, m-CIMT was independently associated with age, VCS and albumin levels. VCS was found to be independently associated with only albumin levels. Conclusion: Vascular and valvular calcification, an indicator of cardiovascular mortality and morbidity in dialysis patients, was found to be significantly associated with malnutrition. We found higher rates of valvular calcification in patients with vascular calcification. Malnutrition was more prominent in these patients.
Keywords : Ateroskleroz, kalsifikasyon, kronik böbrek yetmezliği, inflamasyon, malnütrisyon