Investigation of Neuregulin-1 Gen rs6994992 Polymorphism in Gifted Students in Turkish Population

Authors : Fikriye POLAT, Tuğba BAYRAM, Burcu YÜKSEL

Pages : 1337-1343

Doi:10.16984/saufenbilder.780155

View : 18 | Download : 6

Publication Date : 2020-12-01

Article Type : Research Paper

Abstract :Aim: The aim of this study is to investigate whether neuregulin-1 gene insert ignore into journalissuearticles values(NRG1); rs6994992 polymorphism has any role in gifted students in Turkish population. Methods: During the 2017-2018 academic year, 97 gifted students insert ignore into journalissuearticles values(experiment group); and 99 students with normal development insert ignore into journalissuearticles values(control group); attending 5th grade of different public schools participated in the research. Genomic DNA was extracted from the oral epithelial cells. Genotyping of the molecular variant was performed by Polymerase Chain Reaction- Agarose gel electrophoresis-DNA sequencing techniques. Results: Genotype difference in gifted students was estimated as odds ratio and 95% confidence interval using binary logistic regression models. While the frequencies of CC insert ignore into journalissuearticles values(wild type);, CT insert ignore into journalissuearticles values(heterozygous);, TT insert ignore into journalissuearticles values(polymorphic type); genotypes were 33.0, 53.6 and 13.4%for the experimental group, respectively, they were observed as 33.0, 60.0 and 7.0% in the control group. In the Turkish population, no association could be detected for both genotype and allele distribution for NRG1 rs6994992 C/T polymorphism between gifted and control group insert ignore into journalissuearticles values(OR: 0.538, CI: 0.190-1.525, p = 0.244);. Conclusion: According to the results of our study, there was no relationship between NRG1 rs6994992 polymorphism and gifted students in the Turkish population.
Keywords : NRG1, rs6994992, SNP, gifted, intelligence, Turkish Population