Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII)

Authors : Tuna DEMİRCİ, Oğuzhan ÖZDEMİR, Mustafa Oğuzhan KAYA, Mustafa ARSLAN

Pages : 200-211

Doi:10.16984/saufenbilder.688414

View : 21 | Download : 11

Publication Date : 2021-02-01

Article Type : Research Paper

Abstract :Dihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesized and their effects on carbonic anhydrase II insert ignore into journalissuearticles values(hCAII); have been evaluated. Pyrido [2,3 d] pyrimidines were synthesized from barbituric acid derivatives, malonanitrile, aldehyde derivatives in basic condition and then hydrolyzed with hydrochloric acid. The targeted compounds were syn-thesized from amino sulfanilamide, dihydro [2,3D] pyridine compounds, and triethylorthoformate. 1H NMR, 13C NMR, FT-IR and elemental analysis were used for the structural analysis of the compounds. The half maximal inhibitory concentration insert ignore into journalissuearticles values(IC50); values of the compounds were determined to be between 27.03 and 104.39 μM for hCA II and 19.85-76.64 μM for Ki.
Keywords : Barbituric acid, Carbonic anhydrase II, Dihydro 2 3 D pyridine, Enaminosulfonamide