Metal-containing Coordination Complexes (MCCs): Assessment of Biological Activity with Helicobacter pylori Caused Gastric Ulcer

Authors : Dursun KISA, Yusuf CEYLAN, Merve YILDIRIM, Sümeyra DURGUN, Nesrin KORKMAZ

Pages : 768-775

Doi:10.16984/saufenbilder.1068212

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Publication Date : 2022-08-31

Article Type : Research Paper

Abstract :The ulcer is a vital disease that unfavorably affects human health globally. Helicobacter pylori, a reason forhave an antibacterial effect against ulcers and some stomach disorders, live on using the urease enzyme and induces the condition to occur. Metal coordination complexes insert ignore into journalissuearticles values(MCC); are used in numerous industrial areas and the health field. Cyanide bridged metal complexes are also applied in several places. In the current study, antibacterial characteristic of insert ignore into journalissuearticles values(C1);, [Niinsert ignore into journalissuearticles values(bishydeten);2Aginsert ignore into journalissuearticles values(CN);2][Aginsert ignore into journalissuearticles values(CN);2].H2O);, and insert ignore into journalissuearticles values(C2);, insert ignore into journalissuearticles values([Niinsert ignore into journalissuearticles values(hydeten);2Aginsert ignore into journalissuearticles values(CN);2][Aginsert ignore into journalissuearticles values(CN);2], MCC were analyzed by disk diffusion and broth dilution broth and urease enzyme inhibition assays were performed. As a result of both antibacterial tests, C1 and C2 were observed to provide favorable effects. The synthesized compounds have effective inhibitory potential with IC50 value between 26.65±1.21 and 12.37±0.87 µM for urease.
Keywords : Metal coordination complexes, Helicobacter pylori, antibacterial, enzyme activity, urease