“Double test screening values: Are they different in IVF and spontaneous pregnancies ?”

Authors : Ömür KESKİN, Murat ALAN, Yasemin ALAN, Emrah TÖZ

Pages : 53-59

View : 11 | Download : 8

Publication Date : 2019-12-25

Article Type : Research Paper

Abstract :Objective:  To compare the IVF pregnancy group and spontaneous pregnancy group in terms of PAPP-A and free β-hCG Materials and methods:  Among the pregnant women who applied for double test screening between September 2017 and September 2018, 42 singleton pregnancies that were pregnant as a result of IVF insert ignore into journalissuearticles values(in vitro fertilization); constituted our study group where 109 singleton pregnancies whose age range were matching the IVF pregnacies but were pregnant spontaneously without any assisted reproductive technologies insert ignore into journalissuearticles values(ART); remained in our control group. The demographic data and pregnancy outcomes of both pregnancies were similar. Findings: The mean PAPP-A insert ignore into journalissuearticles values(pregnancy associated plasma protein-A); was found in the control group insert ignore into journalissuearticles values(2.82 mlU / ml; 0.97 MoM);, while in the study group 2.41 mlU / ml, 0.94 MoM);. Free β-hCG insert ignore into journalissuearticles values(beta-human chorionic gonadotropin); values were found as 46.44, ng / ml; 1.21MoM, 53.79ng / ml in control and study groups respectively. The mean PAPP-A of the IVF pregnancy group was lower than the spontaneous pregnancy group, and the mean β-hCG was higher than the spontaneous pregnancy group, but these differences were not statistically significant insert ignore into journalissuearticles values(p> 0.005);. Although not statistically significant; In terms of trisomy 21 we evaluated the study group as higher risk than the control group insert ignore into journalissuearticles values(p> 0.05);. Results: The mean of PAPP-A and free β-hCG values are different in IVF and spontaneous pregnancies, and these differences in biochemical parameters affect the risk of trisomy 21.
Keywords : β hCG, PAPP A, IVF, spontaneous pregnancy