Genetic Variability of Indels in the Prolactin and Dopamine Receptor D2 Genes and Their Association with the Yield of Allanto-Amniotic Fluid in Russian White Laying Hens

Authors : Michael ROMANOV, Natalia V. DEMENTIEVA, Elena S. FEDOROVA, Anna A. KRUTIKOVA, Olga V. MITROFANOVA, Olga İ. STANISHEVSKAYA, Nikolai V. PLESHANOV, Mikhail G. SMARAGDOV, Andrei A. KUDINOV, Valeriy P. TERLETSKY

Pages : 373-379

Doi:10.15832/ankutbd.483561

View : 23 | Download : 10

Publication Date : 2020-09-04

Article Type : Research Paper

Abstract :Currently, there is virtually no information on genetic factors affecting the yield of allanto-amniotic fluid, which is the raw material for the production of human and animal vaccines. Association studies including this trait are beneficial for increasing productivity of a biotechnological line of chickens used for the production of ‘Clean Eggs’. We examined here a population of the Russian White breed for the effects of indels in the prolactin insert ignore into journalissuearticles values(PRL); and dopamine receptor D2 insert ignore into journalissuearticles values(DRD2); genes on the yield of extraembryonic fluid insert ignore into journalissuearticles values(YEF); and embryo weight at 12.5 days of development. A 24-bp insertion in the 5` flanking region of the PRL gene significantly insert ignore into journalissuearticles values(P<0.01); increases YEF in the embryos. The heterozygous embryos contained the highest YEF insert ignore into journalissuearticles values(9.6 mL); than that of the homozygous insertion insert ignore into journalissuearticles values(9.4 mL); and deletion embryos insert ignore into journalissuearticles values(8.4 mL);. We also found a significant association insert ignore into journalissuearticles values(P<0.001); between the PRL genotypes and egg weight insert ignore into journalissuearticles values(EW);. The results of the present study suggest a significant association between the PRL gene variation and quantitative traits in the Russian White chickens, contributing to a long-term programme on the effective use of the genetic potential of Russian gene pool breeds and populations of chickens.
Keywords : Chicken population, Biotechnological line, Candidate genes, Insertion deletion polymorphism, Economically important traits