Assessment of Insulin Resistance, HOMA-IR, and QUICKI Levels in Patients with Endometrial Cancer and Hyperplasia

Authors : Canan Tapkan, Tayfun Güngör, Burçin Salman Özgü

Pages : 119-123

Doi:10.46969/EZH.1527966

View : 30 | Download : 48

Publication Date : 2024-11-06

Article Type : Research Paper

Abstract :Aim: To analyze insulin resistance and related parameters in patients with endometrial cancer and hyperplasia. Methods: The study included 102 patients in 3 groups. Group I and II included patients with a histologic diagnosis of endometrial cancer (n=41, 40.2%) and endometrial hyperplasia (n=31, 30.4%) based on the final pathology report. Group III was the control group and included patients who had undergone surgery for a benign indication other than endometrial hyperplasia (n=30, 29.4%). Age, body mass index (BMI), menarcheal age, menopausal status, gravidity, parity score, diabetes, oral contraceptive status, fasting glucose levels, insulin levels, endometrial thickness, HOMA-IR and QUICKI scores were assessed. Results: The mean age of group I was statistically higher than that of group II (55.3±9.5 vs. 48.8±7.1, p=0.002). The average BMI of the two groups was similar (p=0.076). When fasting glucose values were evaluated, group I showed significantly higher values compared to group II. The mean insulin and HOMA-IR values in the control group were significantly higher than those in group I (p<0.001) and the QUICKI value was significantly higher in group I than in the control group (p=0.026). Conclusion: Insulin resistance appears to be associated with endometrial cancer.
Keywords : insülin direnci, endometrial kanser, hiperplazi