The Role of Inflammatory Markers in Distinguishing Endometrial Polyp: Single Center Results

Authors : Büşra Şahin, Elif Yaman, Fatma Nur Düzenli, Fatih Davran

Pages : 131-136

Doi:10.46969/EZH.1538701

View : 55 | Download : 48

Publication Date : 2024-11-06

Article Type : Research Paper

Abstract :Objective: To investigate the role of inflammatory markers in predicting the presence of endometrial polyps in patients undergoing endometrial sampling due to abnormal uterine bleeding. Methods: The pathology results of patients who presented to Akçakoca State Hospital with abnormal uterine bleeding and underwent endometrial sampling between May 2023 and July 2023 were retrospectively examined. The demographic characteristics of the patients, platelet-lymphocyte, neutrophil-lymphocyte and lymphocyte-monocyte ratios and systemic immune inflammation index were calculated. Patients were categorized into endometrial polyps and other benign pathologies according to the pathological diagnosis. Malignant and premalignant lesions were not included in the study. The examination results and inflammatory markers were compared between these two groups. Results: 89 patients were included in the study. While the pathological finding in 38 patients was an endometrial polyp, other benign pathologies were found in 51 patients. No significant difference was found in terms of hemoglobin, hematocrit, lymphocytes, monocytes, platelets, neutrophils and PDW variables in patients with endometrial polyps (p>0.05). PLR (platelet-to-lymphocyte ratio) and SII (systemic immune-inflammatory index) were significantly higher in the endometrial polyp group compared to other benign pathologies (p<0.05). NLR (neutrophil to lymphocyte ratio) was higher in the endometrial polyp group and was not significant (p: 0.056). SII was 669884.4±410641.7 in the endometrial polyp group and was higher than other benign pathologies. (p<0.05) Conclusion: Endometrial polyps are one of the most important causes of abnormal uterine bleeding. NLR, PLR and SII are parameters of the systemic immune response that can be easily determined with blood tests at no additional cost. SII appears to be an effective and simple test to differentiate endometrial polyps from benign endometrial pathologies.
Keywords : Anormal uterin kanama, Endometrial polip, sistemik immün inflamatuar indeks