The Effects of Methenolone Enanthate Supplement with Exercise on Rats’ Bones

Authors : Mehmet ÖZDEMİR, Sefa LÖK

Pages : 276-280

Doi:10.15314/tsed.555433

View : 12 | Download : 4

Publication Date : 2019-09-15

Article Type : Research Paper

Abstract :Abstract It is known that anabolic steroids are used by athletes to increase their performance and cause many health problems. This study aims to analyze the effects of methenolone enanthate supplement with exercise on rats’ bones. The study was conducted with 28 28-day-old Wistar male rats obtained from the Chair of the Experimental Medicine Researc h and Application Center of Selc uk University. The rats were allocated into four groups: C insert ignore into journalissuearticles values(control, n:6);, E insert ignore into journalissuearticles values(exercise, n:7);, M insert ignore into journalissuearticles values(methenolone enanthate, n:7); and ME insert ignore into journalissuearticles values(methenolone enanthate+exercise, n:8);. The required doses were arranged weekly depending on the rats’ live weight for the groups given methenolone enanthate. The rats’ front and back extremity bones were dissected, and the humerus and femur bones were dried. Each bone’s length, corpus thickness, cortex thickness and medullary diameter points were determined. The results were presented as mean±SD. ANOVA and Duncan`s test were used for inter-group comparison of the data. The threshold for statistical significance was p<0.05. The femur length was 32.46±0.29 in the C group, 32.60±0.64 in the E group, 31.37±0.50 in the ME group and 31.67±0.52 in the M group. The humerus length was 26.42±0.28 in the C group,26.23±0.59 in the E group, 25.31±0.40 in the ME group and 25.35±0.45 in the M group. The femur and humerus length was statistically significantly shorter in the groups that received methenolone enanthate supplement insert ignore into journalissuearticles values(M and ME); than that of the other two groups insert ignore into journalissuearticles values(p<0.05);. No statistically significant difference was found between the C, E, M and ME groups in terms of the cortex and corpus thickness and medullary diameter of their femur and humerus bones insert ignore into journalissuearticles values(p>0.05);. It was concluded based on the study results that methenolone enanthate supplement causes early epiphyseal closure in rats’ femur and humerus bones and stops the increase in these bones’ length. In addition, exercise was found not to reduce this negative effect of methenolone enanthate. Although the prohibited substances classified as anabolics are considered to increase performance by some athletes, these substances are not recommended for use due to their negative effects on athletes’ health.   Keywords: anabolic steroids, methenolone enanthate, rats, femur, humerus
Keywords : anabolic steroids, methenolone enanthate, rats, femur, humerus