The Effects of Exercise on Antioxidant System and Some Blood Parameters at Experimental Diabetic Rats

Authors : Bekir MEHTAP, Zafer DURGUN

Pages : 223-229

Doi:10.15314/tsed.926598

View : 11 | Download : 6

Publication Date : 2021-08-31

Article Type : Research Paper

Abstract :The aim of this study is to determine the effects of exercise on antioxidant system insert ignore into journalissuearticles values(MDA, SOD, GSH); and some blood parameteres insert ignore into journalissuearticles values(plasma insuline, glucose, ALT, AST); in rats with experimental diabetes induced by streptozotocin insert ignore into journalissuearticles values(STZ);. In the study, 32 adult Wistar Albino rats were divided into 4 equal groups as control insert ignore into journalissuearticles values(C);, exercise insert ignore into journalissuearticles values(E);, diabetes insert ignore into journalissuearticles values(D); and diabetes+exercise insert ignore into journalissuearticles values(DE);. Diabetes was induced in D and DE by intraperitoneal injection with a single dose of 60 mg/kg STZ. After the diabetes was induced, swimming exercise was applied to E and DE for 5 days / 30 min a week for 4 weeks. According to the findings obtained; there was a significant decrease in D and DE compared to C. Plasma glucose levels decreased in DE with exercise in the diabetic groups. While ALT levels increased significantly in diabetic groups compared to others, it was found that exercise did not make a difference in diabetics. However, the increase in AST levels was statistically significant only in D. When serum MDA levels were examined, a significant decrease was observed in DE compared to D. While there was a significant decrease in serum SOD levels in the diabetic groups compared to C. The diabetic groups and DE and E were similar to each other. A significant decrease was observed in GSH levels in D. This difference was also detected between diabetic groups. As a result; in the study it was concluded that regular aerobic exercise improved glycemic control, has a lipid peroxidation-reducing effect and may hava a positive effect on strengthening the antioxidant system in diabetes.
Keywords : Antioxidants, exercise, diabetesmellitus, bloodparameters