Vitamin B12 and Folic Acid Levels in Patients with Breath Holding Spells

Authors : Hilal AYDIN, İbrahim BUCAK, Sümeyye ERDOĞAN

Pages : 113-117

Doi:10.12956/tchd.1094163

View : 10 | Download : 4

Publication Date : 2023-03-22

Article Type : Research Paper

Abstract :Objective : Breath holding spells are a benign, non-paroxysmal disorder observed in childhood. The pathogenesis of breath holding spells is still unclear. Dysfunction of the autonomic nervous system, iron deficiency, genetic predisposition, interleukin 1, nitric oxide and cerebral erythropoietin have been implicated in the pathogenesis. The purpose of this study was to compare vitamin B12 and folic acid levels between patients diagnosed with breath holding spells and a healthy group. Material and Methods: Fifty-one cases diagnosed with breath holding spells in the pediatric neurology clinic were included in the study group insert ignore into journalissuearticles values(Group 1);, and 78 healthy patients presenting to the general clinic in the control group insert ignore into journalissuearticles values(Group 2);. Hemoglobin, hematocrit, mean erythrocyte volume, vitamin B12, folic acid, ferritin, iron, and iron binding capacity levels were compared between the study and the control groups. Results: Mean folate levels were 18.92±12.83 insert ignore into journalissuearticles values(5.27-91); ng/mL in the study group and 9.95±8.92 insert ignore into journalissuearticles values(2-37); ng/mL in the control group. Mean B12 levels were 274.13±214.37 insert ignore into journalissuearticles values(75-1201); pg/mL in the study group and 408.82±194.18 insert ignore into journalissuearticles values(120-959); pg/mL in the control group. Statistically significant differences in both vitamin B12 and folic acid levels were observed between the groups insert ignore into journalissuearticles values(p=0.000 and p=0.002, respectively);. No significant difference was determined between the attack groups’ insert ignore into journalissuearticles values(<15/month, >15/month); vitamin B12 insert ignore into journalissuearticles values(p=0.570); or folic acid insert ignore into journalissuearticles values(p=0.643); levels. Conclusion: Based on this study, vitamin B12 and folic acid levels should be routinely evaluated in patients diagnosed with breath holding spells.
Keywords : Çocuk, Folik asit, Tedavi, B12 Vitamini