The Efficacy of Erythrocyte Transfusion in Very Low Birth Weight Infants with Premature Anemia

Authors : Aybüke YAZICI, Betül SİYAH, Ahmet Serkan ÖZCAN, Sevim ÜNAL

Pages : 187-193

Doi:10.12956/tchd.1204367

View : 100 | Download : 165

Publication Date : 2023-05-29

Article Type : Research Paper

Abstract :Objective: This study aimed to determine the clinical efficacy of erythrocyte transfusion insert ignore into journalissuearticles values(ET); in premature infants. Material and Methods: Very low birth weight insert ignore into journalissuearticles values(VLBW); infants with gestational age insert ignore into journalissuearticles values(GA); < 32 weeks and/or birth weight insert ignore into journalissuearticles values(BW); <1500 g and hospitalized in neonatal intensive care unit insert ignore into journalissuearticles values(NICU); between 2012-2018 were retrospectively evaluated. ET was performed according to Ohls 2007 and Turkish Neonatalogy Society Blood Products Transfusion Guidelines. Results: 72 infants included in this study. Mean BW was 1325 g insert ignore into journalissuearticles values(680-2290 g);, GA was 30 weeks insert ignore into journalissuearticles values(25-32);, median postnatal age was 36.7±26.9 days insert ignore into journalissuearticles values(8-129);, number of ET during hospitalization was 2±1.2 insert ignore into journalissuearticles values(1-6);. There were no significant changes in mean heart rates insert ignore into journalissuearticles values(p=0.183); and median respiratory rates before and after ET insert ignore into journalissuearticles values(p=0.123);. Weight gain insert ignore into journalissuearticles values(16 g/day-11 g/day); was statistically similar before and after ET insert ignore into journalissuearticles values(p=0.861);. A significant decrease in apnea, non-invasive ventilation insert ignore into journalissuearticles values(NIV); and caffeine therapy requirements after ET was determined insert ignore into journalissuearticles values(p<0.001, p=0.016 and p=0.016);. Serum lactate insert ignore into journalissuearticles values(2.9-1.5); levels were decreased by ET insert ignore into journalissuearticles values(p=0.017);. Conclusion: Premature infants should closely follow-up for anemia and related symptoms during NICU stay. ET may help to decrease frequency of apnea of prematurity, requirements of caffeine therapy and NIV. ET improves tissue oxygenation in VLBW infants with anemia. Decision of ET should be made according to severity of symptoms, and should be performed according to international, national or local transfusion guidelines.
Keywords : Anemi, Eritrosit Transfüzyonu, Prematüre