Can Platelet Mass Index Be Used as a Prognostic Marker in Children Diagnosed with Multisystem Inflammatory Syndrome Associated with Coronavirus?

Authors : İbrahim EKER, Ayşegül BÜKÜLMEZ, Ayhan PEKTAS, Yeter DÜZENLİ KAR, Nilgün EROĞLU, Mehmet ÇELEGEN, Yiğit ŞENOL, Ayşe ÇITAK, Baran GÜL, Begüm SOYALAN, Deniz DURMUŞ, Melissa KARATAŞ

Pages : 257-262

Doi:10.12956/tchd.1180080

View : 201 | Download : 200

Publication Date : 2023-07-25

Article Type : Research Paper

Abstract :Objective: We’ve aimed at evaluating whether the platelet mass index insert ignore into journalissuearticles values(PMI); can be a prognostic marker for children diagnosed with MIS-C. Material and Methods: 31 children diagnosed with MIS-C and treated at our university hospital between March 2020 and November 2021 were included. Demographic data, clinical findings and laboratory values at the time of hospitalization, admission to the intensive care unit and duration of hospitalization were evaluated retrospectively. PMI of each patient at the time of hospitalization was calculated and recorded. Results: There was a statistically significant negative correlation between PMI and ferritin insert ignore into journalissuearticles values(r= -0.635, moderate, p<0.001);, CRP insert ignore into journalissuearticles values(r= -0.377, weak, p= 0.036);, and procalcitonin insert ignore into journalissuearticles values(r= -0.481, weak, p=0.006); levels. There was a statistically significant positive relationship between PMI and leukocyte count insert ignore into journalissuearticles values(r=0.367, weak, p=0.042); and lymphocyte count insert ignore into journalissuearticles values(r=0.384, weak, p=0.033);. Median PMI values of the patients requiring intensive care insert ignore into journalissuearticles values(1701.35 fl/nl); were lower, compared to the median PMI values of the patients not requiring intensive care insert ignore into journalissuearticles values(2523.94 fl/nl);, however, statistical results could not be reached due to the low insert ignore into journalissuearticles values(4 of 31); number of patients requiring intensive care. Median PMI values of the patients whose ferritin level was >400 ng/ml insert ignore into journalissuearticles values(1415.2; 533.4 – 3600.5); were statistically lower compared to the median PMI values of the patients whose ferritin level was ≤400 ng/ml insert ignore into journalissuearticles values(2705.7; 1395.2 – 9167.6);.Conclusion: The findings in our study demonstrate that low PMI levels identified in children with MIS-C at the time of diagnosis may be with more severe clinical courses
Keywords : çocuk, Koronavirüs Hastalığı, Kitle İndeksi, Multisistem İnflamatuar Sendrom, Trombosit, Prognoz