Relation of Antioxidant Native Thiol Level with Inflammatory Markers and Disease Activity Index in Pediatric Ulcerative Colitis

Authors : Selim DERECİ, Fatih DURAN, Salim NESELİOGLU, Burcu HIDIMOGLU, Duygu İSKENDER MAZMAN, Aysel ÜNLÜSOY AKSU, Arzu Meltem DEMİR, Özcan EREL, Samil HİZLİ

Pages : 309-314

Doi:10.12956/tchd.1260388

View : 94 | Download : 102

Publication Date : 2023-07-25

Article Type : Research Paper

Abstract :Objective: Pediatric ulcerative colitis insert ignore into journalissuearticles values(PUC); is an inflammatory disease. PUC pathogenesis is associated with an imbalance between reactive oxygen species and antioxidant activity which creates oxidative stress. Native thiol insert ignore into journalissuearticles values(NT); level is antioxidant capacity which is practical and repeatable marker of inflammation and antioxidan level. We aimed to analyse the relation of NT level with inflammatory markers and pediatric ulcerative colitis activity index insert ignore into journalissuearticles values(PUCAI);. Material and Methods: Thirty-eight PUC patients insert ignore into journalissuearticles values(SG); and 33 control group insert ignore into journalissuearticles values(CG); participants were included in the study. PUC patients grouped as in remission, mild, moderate and severe activity according to disease activity according to PUCAI. NT, hemoglobin insert ignore into journalissuearticles values(Hb);, white blood cell insert ignore into journalissuearticles values(WBC);, platelet insert ignore into journalissuearticles values(PLT);, mean platelet volume insert ignore into journalissuearticles values(MPV);, albumin, C-reactive protein insert ignore into journalissuearticles values(CRP);, erythrocyte sedimentation rate insert ignore into journalissuearticles values(ESR);, interleukin 6 insert ignore into journalissuearticles values(IL-6); levels of all participants were measured at the time they were enrolled in the study and recorded. Results: Mean age and gender ratio of groups were similar insert ignore into journalissuearticles values(p>0.050);. NT level of SG statistically high compared to CG insert ignore into journalissuearticles values(p=0.001);. Hb, PLT, MPV, CRP, ESR, IL-6 levels of SG were statistically different than CG insert ignore into journalissuearticles values(p=0.045, p=0.026, p=0.001, p=0.001, p=0.001, p=0.001);. NT level of SG was positively correlated with Hb, MPV, albumin insert ignore into journalissuearticles values(p=0.001, for all);. NT level of SG was negatively correlated with PLT, CRP, ESR, IL-6 and PUCAI insert ignore into journalissuearticles values(p=0.001);. Conclusion: NT level of PUC is significantly lower than CG. NT level of SG was positively correlated with albumin which is a good prognostic factor in PUC patients. NT may be repeatable, noninvasive candidate serum biomarker for PUC management.
Keywords : Aktivite, Antioksidan, Çocuk, Native tiyol, Ülseratif kolit