Clinical Evaluation of Pediatric Patients Diagnosed with Membranous Glomerulonephritis

Authors : Deniz KARAKAYA, Fatma YAZILITAŞ, Evrim KARGIN ÇAKICI, Tülin GÜNGÖR, Evra ÇELİKKAYA, Mehmet BÜLBÜL

Pages : 341-346

Doi:10.12956/tchd.1236249

View : 73 | Download : 77

Publication Date : 2023-09-25

Article Type : Research Paper

Abstract :Objective: Membranous nephropathy insert ignore into journalissuearticles values(MN); is a rare immune complex disease in pediatric population then adults. The prognosis of MN is variable, ranging from spontaneous complete remission to end-stage renal disease insert ignore into journalissuearticles values(ESRD);. The lack of large multicenter studies precludes the possibility of examining in detail the treatment options and clinical outcomes in these patients. The present study aimed to expand the literature on the clinical findings, treatment, and prognosis of MN in pediatric patients. Material and Methods: This single-center retrospective study included 13 patients with a diagnosis of primary and secondary membranous nephropathy. Results: The mean age of the sample was 12.29±3.67 years. Complete remission occurred in 7 insert ignore into journalissuearticles values(53.8%); patients insert ignore into journalissuearticles values(of which 1 case was spontaneous remission);, and partial remission occurred in 4 insert ignore into journalissuearticles values(30.8%); patients. In long-term follow-ups; one patient had chronic kidney disease insert ignore into journalissuearticles values(CKD); and one patient had end-stage renal disease insert ignore into journalissuearticles values(ESRD);. At the last-follow up, proteinuria was noted in 6 insert ignore into journalissuearticles values(46.2%); patients and microscopic hematuria was noted in 4 insert ignore into journalissuearticles values(30.8%); and 9 patients were still using low-dose steroids. Conclusion: The current findings have not identified any significant risk factors associated with the prognosis of MN in pediatric patients, but are thought to contribute to the limited data on pediatric MN. Most of the available data on the natural history, treatment options, and long-term outcomes of MN in the pediatric population consists of small, uncontrolled case series. Therefore, we think that larger-scale clinical trials are necessary to clearly elucidate the factors related to the prognosis of pediatric MN.
Keywords : membranöz glomerülonefrit, çocukluk çağı, nefrotik sendrom, nefritik sendrom