Evaluation of Serum Renalase in Children with Recurrent Urinary Tract Infection and Renal Scars

Authors : Melike Arslan, Umut Selda Bayrakçı, Halil İbrahim Yakut, Ali Ata Çerkezoğlu

Pages : 338-341

Doi:10.12956/tchd.1459460

View : 49 | Download : 98

Publication Date : 2024-11-18

Article Type : Research Paper

Abstract :Objective: Recurrent urinary tract infections (UTI) are important risk factors for renal scarring. The aim of the study was to assess the relationship between renalase and renal scars in children. Material and Methods: The study included 78 patients with recurrent UTI and 20 healthy controls. All patients had voiding cystourethrography and dimercaptosuccinic acid (DMSA) scintigraphy. Serum renalase level were analyzed in children with recurrent UTI and controls. Results: The study included the 78 patients with a history of recurrent UTI (7 boys, 9.0%; 71 girls, 91.0%) and 20 healthy children (3 boys, 15%; 17 girls, 85%) were included in the study. The mean age of the patients and healthy controls were 11.71±0.91 years and 12.35±1.83 years, respectively. Vesicoureteral reflux (VUR) was detected in 48.7% of patients (38/78). Of 45 recurrent UTI with renal scar, 71% also had VUR. The renalase level of the recurrent UTI group was found to be significantly higher than the control group (p=0.014). Renalase level was found to have a significant relationship with renal scars. The mean renalase level of the scar group was found to be significantly higher than the scar-free group (p=0.005). It was found that there was no statistical difference between the renalase means of children with scars depending on whether they had VUR or not (p=0.688). Conclusion: This study suggests that renalase may play an important role in the formation of renal fibrosis and scars. After clarifying the role of renalase in renal scarring, it might come up as a new agent to prevent fibrosis and scar tissue development in patients with recurrent urinary tract infections.
Keywords : Çocuklar, Tekrarlayan idrar yolu enfeksiyonu, Renalaz, Renal skar, Vezikoüreteral reflü