Comparison of different endometrial preparation protocols in frozen-thawed embryo transfer cycles in women with polycystic ovary syndrome

Authors : Murat ÖNAL, Mehmet AĞAR, Ayşe Şeyma KÜÇÜKAKÇA, Tuğba GÜRBÜZ

Pages : 34-38

Doi:10.38053/acmj.1218259

View : 11 | Download : 8

Publication Date : 2023-01-20

Article Type : Research Paper

Abstract :Aim: This study aimed to evaluate the most suitable endometrial preparation protocols such as hormone replacement therapy insert ignore into journalissuearticles values(HRT); with gonadotropin releasing hormone analogue insert ignore into journalissuearticles values(GnRH-a); suppression, HRT without GnRH-a suppression and mild ovarian stimulation insert ignore into journalissuearticles values(OS); for women with  polycystic ovary syndrome insert ignore into journalissuearticles values(PCOS); undergoing frozen-thawed embryo transfer insert ignore into journalissuearticles values(FET);. Material and Method: We conducted a historical cohort analysis of 161 women with PCOS who underwent the “freeze-all” strategy between December 2018 and August 2020 because of their high risk for ovarian hyperstimulation syndrome. Three endometrial preparation protocols were used: HRT with GnRH-a suppression insert ignore into journalissuearticles values(n=43);; HRT without GnRH-a suppression insert ignore into journalissuearticles values(n=86);; mild-OS insert ignore into journalissuearticles values(n=32);. Results: The biochemical pregnancy results insert ignore into journalissuearticles values(55.8 % vs 54.65 % vs 53, p=0.900);, ongoing pregnancy rates insert ignore into journalissuearticles values(44.2 % vs 43 % vs 40.62, p=0.572);, and abort rates insert ignore into journalissuearticles values(20.8 % vs 21.3 % vs 23.52, p=0.900); were similar between the HRT with GnRH-a suppression, without GnRH-a suppression and mild-OS, respectively. This study showed no statistically significant difference between the three protocols in laboratory parameters insert ignore into journalissuearticles values(p>0.05);. Conclusion: There was no statistically difference between three groups in terms of pregnancy outcomes. Dependent on clinical experience and facility, one of these protocols could be deployed for FET in women with PCOS.
Keywords : Frozen thawed embryo, GnRH a, implantation, polycystic ovary syndrome