- Ankara Üniversitesi Eczacılık Fakültesi Dergisi
- Volume:47 Issue:2
- TOXIC EFFECTS OF AROCLOR 1254 ON RAT HEART AND THYROID AND MODIFYING ROLE OF SELENIUM STATUS
TOXIC EFFECTS OF AROCLOR 1254 ON RAT HEART AND THYROID AND MODIFYING ROLE OF SELENIUM STATUS
Authors : Aylin BALCI ÖZYURT, Gizem ÖZKEMAHLI, Ünzile YAMAN, Ali AŞCI, Murat KIZILGÜN, Pınar ERKEKOĞLU, Belma KOÇER GÜMÜŞEL
Pages : 408-419
Doi:10.33483/jfpau.1217709
View : 14 | Download : 6
Publication Date : 2023-05-20
Article Type : Research Paper
Abstract :Objective: Polychlorinated biphenyls insert ignore into journalissuearticles values(PCBs); were very widely used in industrial products in past. These chemicals were banned in the 1970s due to their toxic effects. PCBs can still affect human health, as they are persistent in the environment. Aroclor 1254 insert ignore into journalissuearticles values(A1254); is a commercial PCB congener which was used in electrical transformers, fluorescent lighting fixtures and old appliances such as televisions or refrigerators. In this study, we aimed to evaluate the toxic effects of A1254 on heart and thyroid in male Sprague-Dawley rats. In addition, the modifying role of selenium status was also evaluated. Material and Method: 8-week-old male Sprague-Dawley insert ignore into journalissuearticles values(SD); rats were used in the experiment. The animals were separated randomly into 6 groups insert ignore into journalissuearticles values(n=6); as control; selenium supplemented insert ignore into journalissuearticles values(SeS);; selenium deficient insert ignore into journalissuearticles values(SeD);; A1254 exposed insert ignore into journalissuearticles values(A);; selenium supplemented A1254 exposed insert ignore into journalissuearticles values(ASeS); and selenium deficient A1254 exposed insert ignore into journalissuearticles values(ASeD);. A1254 was applied by gavage during the last 15 days of feeding period. Heart and thyroid weights and relative weights, plasma thyroid hormone levels, as well as thyroid and heart tissue oxidative/antioxidative parameters were evaluated. Result and Discussion: Results showed that A1254 exposure and selenium deficiency caused oxidative stress on both heart and thyroid. Plasma fT3 and fT4 levels markedly changed in ASeD group. In conclusion, it can be stated that A1254 exposure can cause lead to oxidative/antioxidative imbalance in both thyroid and heart and can disrupt functioning of thyroid hormones. Selenium seems to have a modifying role in A1254 toxicity in both organs, the importance of which should be evaluated with further mechanistic experiments.Keywords : Aroklor 1254, kardiyotoksisite, oksidatif stress, selenyum, tiroit bozuklukları