SELF EMULSIFYING DRUG DELIVERY SYSTEMS - AN OVERVIEW

Authors : Naz BAYTOK, Ongun Mehmet SAKA

Pages : 705-718

Doi:10.33483/jfpau.1244378

View : 12 | Download : 7

Publication Date : 2023-05-20

Article Type : Review Paper

Abstract :Objective: Self-Emulsifying Drug Delivery System insert ignore into journalissuearticles values(SEDDS); has tremendous potential that has yet to be completely realized. They can be used in the formulation of drug compounds that have low water solubility in oral lipid administration and overcome many problems associated with these compounds. The SEDDS can increase the rate and degree of oral absorption by optimizing drug solubility in the intestinal absorption site, attributable to its small particle size, large surface area, high encapsulation efficiency, and high drug load. Furthermore, due to its lipid-based formulation, SEDDS can accelerate and increase pharmaceutical lymphatic transport, bypassing hepatic first-pass metabolism and therefore enhancing bioavailability. Result and Discussion: The quantity of novel therapeutically effective lipophilic molecules that are hydrophobic has steadily increased thanks to innovative drug development approaches. The future of pharmaceutical research may not only pass through the discovery of new molecules but also better exploitation of those already known. The use of SEDDS has been proven to be quite successful in enhancing the oral bioavailability of hydrophobic and lipophilic drug molecules among the strategies to increase the oral bioavailability of these compounds.
Keywords : Emülsifiye dozaj formları, ilaç çözünürlüğü, kendiliğinden emülsifikasyon, kendiliğinden emülsifiye olabilen ilaç taşıyıcı sistemler, lipofilik ilaçlar