PREPARATION AND CHARACTERIZATION OF CARBOPOL BASED HYDROGELS CONTAINING DEXPANTHENOL

Authors : Emre Şefik ÇAĞLAR, Gökçe KARAOTMARLI GÜVEN, Neslihan ÜSTÜNDAĞ OKUR

Pages : 770-783

Doi:10.33483/jfpau.1195397

View : 142 | Download : 306

Publication Date : 2023-09-20

Article Type : Research Paper

Abstract :Objective: The purpose of this study is to create dexpanthenol-loaded hydrogel formulations to alter the release patterns and enhance the physicochemical qualities of the market product. Material and Method: To make hydrogel formulations, Carbopol Ultrez was utilized in concentrations of 1%, 1.5%, and 2% insert ignore into journalissuearticles values(w/w);. The active component dexpanthenol was then added to the formulations at a concentration of 5% insert ignore into journalissuearticles values(w/w);. pH, viscosity, texture profile analysis, spreadability, bioadhesion, and in vitro release characteristics were all assessed for the formulations. Result and Discussion: The formulations were found to be suitable for cutaneous application. TPA analysis revealed that the G1 and G1-DXP formulations had the hardness value 10.1851.219 and 30.8541.637 g, respectively. That formulations’ bioadhesion strength has grown because they are more flexible than previous formulations while having low hardness values. As such, it has been observed that the formulations release more than 50% of DXP in three hours while the market preparation was not even reach the 10% drug release. In the in vitro release kinetics study, it was calculated that all formulations fit the Higuchi model. As a result, a more effective drug delivery system has been developed compared to the market preparation. The currently prepared formulations are also promising formulations in terms of their use in treatment.
Keywords : Dekspantenol, hidrojel, karakterizasyon, karbopol