EFFECTS OF DRYING TEMPERATURE ON CURCUMIN AND PIPERINE DISSOLUTION AND THE RELEASE KINETICS OF SOLID DISPERSION-BASED MICROPARTICLES: A PRELIMINARY STUDY

Authors : Monica Octaviani Tiara DEWİ, Dewi SETYANİNGSİH

Pages : 853-863

Doi:10.33483/jfpau.1253561

View : 37 | Download : 41

Publication Date : 2023-09-20

Article Type : Research Paper

Abstract :Objective: One of the major challenges in developing curcumin as a pharmaceutical agent is its low bioavailability after oral administration. Co-administration of curcumin-piperine combined with employing solid dispersions insert ignore into journalissuearticles values(SD); approach has been shown to enhance curcumin dissolution and bioavailability. Understanding the influence of the processing temperature during spray drying is crucial in SDs preparations; the purpose of this study is to inquire the effect of inlet temperature spray-dryer on dissolution behavior and the best-fit kinetic model of dissolution itself. Material and Method: The SD powder was prepared using a spray-drying method by varying the inlet temperature insert ignore into journalissuearticles values(105°C; 115°C; 125°C); and involved polyvinyl alcohol insert ignore into journalissuearticles values(PVA); as a carrier. The SD were prepared at 30% Curcuma longa and 10% Piper nigrum extracts. Yield insert ignore into journalissuearticles values(%); of the dried powder resulted from the spray drying process was monitored, and dissolution behavior of curcumin and piperine were analyzed using a dissolution efficiency insert ignore into journalissuearticles values(DE); value. Furthermore, mathematical model describing the release mechanism of curcumin and piperine from the dissolution were evaluated using a DDSolver software. Result and Discussion: The variation of drying temperature on the spray dryer affects the dissolution behavior and the % yield of the PVA-based SD containing C. longa and P. nigrum extract. The most ideal mathematical model of kinetic release for curcumin and piperine were the Quadratic model, indicating that the mechanism of dissolution is diffusion through a gap between the PVA particle and the surrounding medium.
Keywords : Curcuma longa, çözünme, DDSolver, katı dispersiyon, Piper nigrum