ANTIOXIDANT, ENZYME INHIBITORY, AND CYTOTOXIC ACTIVITY SCREENING OF MYRTUS COMMUNIS L.

Authors : Esra KÖNGÜL ŞAFAK, Selen İLGÜN, Kübra Nur ÇOBAN, Sena AKÇAKAYA MUTLU, Halil YILMAZ, Gökçe ŞEKER KARATOPRAK

Pages : 827-835

Doi:10.33483/jfpau.1264321

View : 74 | Download : 69

Publication Date : 2023-09-20

Article Type : Research Paper

Abstract :Objective: The present study aimed to evaluate the biological activities of Myrtus communis L., which has traditional medicinal use for different purposes, from a broad perspective. Material and Method: The antioxidant insert ignore into journalissuearticles values(DPPH, ABTS, total phenol, and flavonoid amounts); anti-inflammatory insert ignore into journalissuearticles values(LOX enzyme inhibition);, antidiabetic insert ignore into journalissuearticles values(α-glucosidase enzyme inhibition);, and cytotoxic properties insert ignore into journalissuearticles values(MTT assay); of a 70% methanol extract made from leaves and dichloromethane, butanol, ethyl acetate, and the residual water fractions were investigated. Result and Discussion: The DPPH radical scavenging effect of the ethyl acetate fraction, with the highest total phenol and flavonoid content, was found to be 1.4 µg/ml, and the ABTS radical scavenging effect was 2.58 mmol/Trolox. The most potent inhibitor of LOX insert ignore into journalissuearticles values(IC50: 31.17 µg/ml); and α-glucosidase insert ignore into journalissuearticles values(96% inhibition at 0.5 mg/ml); enzymes was determined as ethyl acetate extract. Dichloromethane fraction was shown to have the most cytotoxic activity in both Hela and Colo cell lines. This research has given us a better understanding of the traditional use of the M. communis plant, which stands out for its therapeutic properties.
Keywords : Antioksidan, sitotoksik aktivite, enzim inhibisyonu, Myrtus communis