CRITICAL POINTS OF INTERFERENCE AND PROBABLE INFLUENCE ON THE VALIDITY OF RESULTS OF A BIOCHEMICAL MEDICAL ANALYSIS: STATISTICAL APPROACH

Authors : Habiba Berbaoui, Abdenbi Asma, Seghir Abdelhadi, Touati Boumedienne

Pages : 1293-1302

Doi:10.33483/jfpau.1443744

View : 237 | Download : 116

Publication Date : 2024-11-25

Article Type : Research Paper

Abstract :Objective: The manipulator must be aware that some results obtained by the various biochemical analysis methods may be erroneous and don’t represent reality. For this, the biochemist is asked to identify the critical points responsible for the aberration of the results obtained and it is imperative that he be aware of all the factors that can induce the modification of the results obtained. The influencing factors listed are the results of long practical experience within a biochemical analysis laboratory supplemented by bibliographic research that we have brought together in an educational document in the form of a guide and of which the statistical study is reported by the present study. Material and Method: Through this study, we used the Ichikawa diagram of Hazard Analysis Critical Control Point to list and organize all the factors of influence and probable interference on the results of a biochemical medical analysis, subsequently, we determined the influence rates of each factor as well as all the factors linked to it. The statistical study carried out relates to the pre-analytical, analytical and post-analytical stages of a biochemical analysis. The rates obtained represent the influence of an isolated factor or a common set of factors in relation to all the factors determined. Result and Discussion: The critical points of interference and influence on the validity of the results obtained have been listed through all the steps of a biochemical analysis with variable rates of 60.26%, 28.75% and 07.84% respectively for the pre- analytical stage, analytical and post analytical stage; The highest rate for the pre--analytical stage was represented by factors related to patient with a rate of 35.29%,concerning the analytical stage, the materials used presented a rate of 11.11% for the post-analytical stage, factors that could interfere with the measurement presented a rate of 05.58%.
Keywords : Analiz, biyokimyasal, HACCP, girişim, etki