AN OVERVIEW OF 3D PRINTING TECHNOLOGIES FOCUSING MULTIDRUG-LOADED 3D PRINTED DOSAGE FORMS

Authors : Aysel Yılmaz, Başaran Mutlu Ağardan, Sevgi Takka

Pages : 228-240

Doi:10.33483/jfpau.1553409

View : 47 | Download : 105

Publication Date : 2025-01-20

Article Type : Review Paper

Abstract :Objective: This review focuses on multidrug-loaded dosage forms produced with three-dimensional printing (3DP) technologies since the confirmation of Spritam®, the first 3D printed dosage form, in 2015. Result and Discussion: The integration of multiple drugs within a single dosage form through 3DP offers substantial flexibility in design, allowing for the customization of dosage, drug release profiles, and geometric structures. These formulations offer significant design flexibility by combining different drugs in a single unit, and have the potential to optimize treatment strategies, especially for diseases requiring multiple drug use. The wide literature search reveals that the most commonly used method is Fused Deposition Modeling (FDM) to obtain 3D printed dosage forms with various geometries, such as multi-compartment capsules or tablets, bi-layered or multi-layered tablets exhibiting different release kinetics, and core/shell structured tablets. Multidrug-loaded 3D-printed dosage forms have significant potential for individualizing fixed-dose combinations and have become a promising tool for advancing personalized medicine and improving therapeutic outcomes for polypharmacy. This innovative approach can optimize therapeutic efficacy, reduce side effects, and improve patient compliance. As research continues to expand, these formulations represent a promising direction for the future of drug development and treatment strategies.
Keywords : 3DP teknolojisi, çoklu ilaç yüklü 3D çıktılar, kişiselleştirilmiş tıp, polipiller