The Impact of Lactate Clearance, Bilirubin, and Albumin on Mortality in Elderly COPD Patients: Insights from Emergency Department Data

Authors : Mahmut Yaman, Abdullah Şen, Hasan Mansur Durgun, Sema Belek, Murat Orak, Veysi Tekin, Ercan Gündüz, Cahfer Güloğlu

Pages : 153-158

Doi:10.54996/anatolianjem.1541724

View : 44 | Download : 82

Publication Date : 2024-12-30

Article Type : Research Paper

Abstract :Aim: Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterized by symptoms such as cough, dyspnea, and airflow limitation. The prevalence and health risks of COPD increase with age, making emergency interventions crucial for elderly patients. This study investigated the influence of bilirubin, lactate clearance, and albumin levels on mortality rates among elderly COPD patients in emergency settings to inform treatment strategies and improve clinical outcomes. Material and Methods: Elderly patients diagnosed with COPD were included in this retrospective cohort study. Data on demographics, clinical presentations, laboratory results, comorbidities, and outcomes were collected. Biochemical measurements were performed via biochemical analyses and arterial blood gas analyses. Results: Among the 139 patients studied, 89 (64%) were male with a mean age of 75 years. The mortality rate was 7.92%. No significant differences were observed in age, sex distribution, or comorbidities between deceased and surviving patients. Lactate clearance and bilirubin levels did not significantly affect mortality. However, albumin levels were notably lower in deceased patients (p<0.05). Univariate analysis revealed significant effects of PO₂, neutrophil, and albumin levels on mortality, whereas the multivariate model confirmed that PO₂ and albumin levels were significant predictors. Conclusion: This study highlights the prognostic value of biochemical markers in predicting mortality among elderly COPD patients in emergency settings. While lactate clearance and bilirubin levels are not reliable predictors of mortality, lower albumin levels are strongly associated with increased mortality risk. These findings underscore the importance of the serum albumin concentration as a critical biomarker in the clinical assessment of elderly COPD patients.
Keywords : Kronik obstrüktif akciğer hastalığı, bilirubin, laktat klirensi, albümin, yaşlı