Infections and causative microorganisms in patients with ANCA-associated vasculitis

Authors : Gizem VARKAL, İpek TÜRK, Özlem DOĞAN AĞBUGA, Mehmet Ali AŞIK, Şerife Şeyda ZENGİN ACEMOĞLU, Kaniye AYDIN, Didem ARSLAN, Hüseyin Turgut Elbek ÖZER

Pages : 253-260

Doi:10.17826/cumj.1218642

View : 14 | Download : 10

Publication Date : 2023-03-31

Article Type : Research Paper

Abstract :Purpose: The aim of this study was to detect infections requiring hospitalization in patients with ANCA-associated vasculitis insert ignore into journalissuearticles values(AAV);. Materials and Methods: This is a single-center, retrospective study conducted in Turkish patients with AAV. Infection episodes requiring hospitalization, reproducing pathogens, laboratory findings, immunosuppressive treatments given for the treatment of vasculitis, and the relationship with the infection were evaluated. Results: Seventy-four patients diagnosed with AAV were included in the study. Hospitalization due to infection was observed in 36 of the patients. The coexistence of diabetes mellitus insert ignore into journalissuearticles values(DM); was found to be significantly higher in the infected patient group. Cyclophosphamide insert ignore into journalissuearticles values(CYC); treatment found to increase risk of infection. More than 80% of the infected patient group presented with renal involvement insert ignore into journalissuearticles values(80.6%);. A total of 68 infectious episodes were seen in 36 patients. The most common involvement of infection was the respiratory tract with a rate of 70.6%. Gram-negative bacteria were the most common pathogen, especially Pseudomonas aeruginosa. With the effect of the pandemic, SARS-CoV-2 has come to the fore among viral infections. Aspergillosis was the most frequently detected among fungal infections. Besides, aspergillosis was the cause of 85.7% insert ignore into journalissuearticles values(6 episodes); of fungal infections. Lymphopenia was observed in 76.5% of the infection episodes. 57.4% of infections developed in the first year of the induction therapy. The most frequently used immunosuppressive therapy for the treatment of vasculitis in infectious episodes was CYC insert ignore into journalissuearticles values(41.2%);. Conclusion: Managing infections during the vasculitis treatment is crucially important. Lymphopenia, kidney involvement, DM and immunosuppressive therapy are factors that increase the risk of infection. Clinicians should take preventive measure especially for respiratory tract infections and gram-negative bacteria as pathogens.
Keywords : ANCA ile ilişkili vaskülit, enfeksiyon, immünsüpresyon, lenfopeni