COVID-19 and persistent inflammation, immunosuppression and catabolism syndrome

Authors : Derya TATLISULUOĞLU, Güldem TURAN

Pages : 441-447

Doi:10.17826/cumj.1229091

View : 35 | Download : 180

Publication Date : 2023-07-02

Article Type : Research Paper

Abstract :Purpose: Multiple organ failure insert ignore into journalissuearticles values(MOF); is a disease group that necessitates intensive care monitoring and carries a significant mortality rate. If these individuals are not dead as a result of early MOF, they will either quickly restore immunological balance or their immunological dysfunction may persist, resulting in chronic critical illness insert ignore into journalissuearticles values(CCI);. Some of these patients have CCI, which is characterized by chronic inflammation, immunosuppression, and the syndrome of catabolism insert ignore into journalissuearticles values(PICS);. With this study, we aimed to evaluate PICS cases in our intensive care unit, their effects on mortality, and their biomarkers. Materials and Methods: This is a retrospective, observational study involving 190 patients diagnosed with acute respiratory distress syndrome insert ignore into journalissuearticles values(ARDS); due to SARS-CoV-2 and followed up in the ICU. Patients\` laboratory data and body mass index insert ignore into journalissuearticles values(BMI); were compared between the first and twenty-first days of ICU admission. In addition, the patients were evaluated according to PICS utilizing the number of days they spent in the ICU, CRP, albumin, prealbumin, lymphocytes, and BMI data. Results: The laboratory values of the patients on the 21st day were as follows, and the results obtained were statistically significant when compared with the values on the 1st day. Albumin 2.56±0.57 g/L, prealbumin 9±15 g/L, d-dimer 4.41±4.70 insert ignore into journalissuearticles values(interquartile range insert ignore into journalissuearticles values(IQR);: 2.53-4.76); µgFEU/mL, fibrinogen 497±189,35 mg/dl, hemoglobin 10.15±1.82 g/dL, leukocytes 13.94±8.12 insert ignore into journalissuearticles values(IQR: 12.34-7.69); 109/L, immature granulocyte 1.16±2.13 insert ignore into journalissuearticles values(IQR: 0.46-1);109/L and BMI of 26.92±3.27 insert ignore into journalissuearticles values(IQR: 26.7-4.8);. Again in these patients, lymphocyte values were 0.92±0.80 insert ignore into journalissuearticles values(IQR: 0.71-0.74);109/L, CRP was 101.42±99,96 mg/L, and platelet values were 214.24±128.08 109/L. Conclusion: PICS is a significant condition affecting mortality and morbidity in critical care patients. In this group of patients, immature granulocytes may also serve as a useful biomarker. Due to the lack of studies regarding PICS, we are in the premature phase of understanding the pathogenesis and management of PICS and therefore need more comprehensive research regarding the topic.
Keywords : Persistent İnflamasyon, immünsüpresyon, katabolizma sendromu, PICS, covid 19