Systemic immune inflammation index may be a new powerful marker for the accurate early prediction of complications in patients with acute appendicitis

Authors : Hüseyin MUTLU, Ekrem Taha SERT, Kamil KOKULU, Yakup USLU

Pages : 679-685

Doi:10.17826/cumj.1276128

View : 55 | Download : 129

Publication Date : 2023-07-02

Article Type : Research Paper

Abstract :Purpose: To investigate the relationship between the systemic immune-inflammatory index insert ignore into journalissuearticles values(SII); and acute appendicitis insert ignore into journalissuearticles values(AA);. Materials and Methods: We retrospectively evaluated patients aged over 18 years who were diagnosed with AA and underwent surgery at our clinic from January 1, 2019, through July 31, 2022. The patients were divided into three groups: complicated acute appendicitis insert ignore into journalissuearticles values(CAA);, uncomplicated acute appendicitis insert ignore into journalissuearticles values(UAA);, and control. The clinical and laboratory characteristics of the patients evaluated at the emergency department were recorded. The neutrophil/lymphocyte ratio insert ignore into journalissuearticles values(NLR);, the platelet/lymphocyte ratio insert ignore into journalissuearticles values(PLR);, and SII insert ignore into journalissuearticles values(neutrophil count x platelet count/lymphocyte count); were calculated. Results: The study included a total of 1,456 patients, of whom 628 had UAA, 104 had CAA, and 714 were controls. The NLR, PLR, and SII values were statistically significantly higher in the CAA group than in the control group and the UAA group. The multivariate logistic regression analysis revealed that SII was an independent predictor of CAA development insert ignore into journalissuearticles values(odds ratio [OR]: 4.65; 95% confidence interval [CI]: 2.31–10.17);. The predictive power of SII in the prediction of CAA insert ignore into journalissuearticles values(area under the curve [AUC]: 0.809); was much higher than that of NLR insert ignore into journalissuearticles values(AUC: 0.729);, neutrophil count insert ignore into journalissuearticles values(AUC: 0.696);, and C-reactive protein insert ignore into journalissuearticles values(AUC: 0.732); alone. It was determined that an SII value greater than 1,989.2 had a sensitivity of 78.4% and a specificity of 88.5% in predicting CAA development. Conclusion: SII is a simple, inexpensive, and promising marker that could predict both the diagnosis and severity of appendicitis.
Keywords : Sistemik immün inflamatuar indeks, akut apandisit, acil servis