A new marker in determining the relationship between the clinical outcomes of patients with sepsis and thyroid function tests: free triiodothyronine to free thyroxine ratio

Authors : Esra YAKIŞIK, Çiğdem YÜCEL, Murat KIZILGÜN, Işıl ÖZKOÇAK TURAN

Pages : 1106-1114

Doi:10.17826/cumj.1310083

View : 14 | Download : 34

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Purpose: This study investigated the predictive value of thyroid hormones in septic patients. Materials and Methods: Our study was conducted in patients with sepsis in intensive care unit insert ignore into journalissuearticles values(ICU);. Free triiodothyronine insert ignore into journalissuearticles values(fT3); and free thyroxine insert ignore into journalissuearticles values(fT4); levels taken at the time of hospitalization and at the 48th hours were measured and the fT3 / fT4 ratio was calculated. Calculated fT3 and fT4 change between first and 48th hours. Results: 192 patients with sepsis were included in the study. In non-survivor patients, first fT3 insert ignore into journalissuearticles values(1.60±0.57 ng/dL v.s. 2.01±0.41 ng/dL); and fT3 / fT4 ratio insert ignore into journalissuearticles values(1.34±0.88 v.s. 1.79±0.91); were found to be significantly lower than 48th hours fT3 insert ignore into journalissuearticles values(0.77±0.39 ng/dL v.s. 1.87±0.49 ng/dL); and fT3 / fT4 ratio insert ignore into journalissuearticles values(0.60±0.51 v.s. 1.66±1.21); survivors. It was found that the first fT3 levels insert ignore into journalissuearticles values(-0.83±0.45 v.s. -0.23±0.14); and fT3 / fT4 ratio insert ignore into journalissuearticles values(-0.73±0.62 v.s. -0.12±0.11); decreased significantly more at 48th hour in non-survivors than survivors. The 48th hours fT3 level and the change in fT3 between the first and 48th hour were found to be the most significant parameters for the mortality indicator. Conclusion: fT3 / fT4 ratio has predictive value for mortality in patients with sepsis in ICU. In addition, fT3 was found to be an indicator for mortality predictivity both at admission and at 48th hours.
Keywords : Serbest triiyodotironin serbest tiroksin oranı, Yoğun bakım ünitesi, Sepsis, Tiroksin, Triiyodotironin