Antibiotic-related adverse events and risk factors in hospitalized patients: a prospective cohort study

Authors : Orcun SOYSAL, İrfan ŞENCAN, Nesibe KORKMAZ

Pages : 1024-1032

Doi:10.17826/cumj.1311112

View : 15 | Download : 29

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Purpose: The objective of this study is to identify antibiotic-related adverse events and risk factors in hospitalized patients. Materials and Methods: This prospective cohort study included 776 inpatients who received antibiotic treatment between January 2019 and December 2020. Patients who experienced \`definite\` or \`probable\` adverse drug events insert ignore into journalissuearticles values(ADE); were examined using the World Health Organization-Uppsala Monitoring Center insert ignore into journalissuearticles values(WHO-UMC); criteria. The definition and severity criteria for antibiotic-related adverse events were determined according to the Common Terminology Criteria for Adverse Events insert ignore into journalissuearticles values(CTCAE);. Results: The overall rate of antibiotic-associated ADE was 7.9 insert ignore into journalissuearticles values(95%CI, 6.8-9.1); per 1000 person-days. The study identified a total of 152 adverse events in 125 patients who experienced ADE. Among the 152 adverse events, 63 insert ignore into journalissuearticles values(41.4%); were severe, and 89 insert ignore into journalissuearticles values(58.6%); were non-severe. Independent risk factors for ADE included the number of comorbidities insert ignore into journalissuearticles values(up to 4 times higher increased risk);, number of drugs used, and duration of antibiotic administration insert ignore into journalissuearticles values(up to 12.3 times higher and 8% increased risk for each additional day);. The most common side effects were hematological, with 45 insert ignore into journalissuearticles values(29.6%); cases reported in the hematological system advers events. Conclusion: The management of antibiotic durations, which is a controllable factor in the development of antibiotic-related adverse events, is crucial. Rational use of antibiotics is essential, not only in terms of preventing the development of resistance but also in terms of reducing the frequency of adverse events that may become life-threatening.
Keywords : Advers olaylar, antibiyotikler, risk faktörleri