Comparison of visceral adipose tissue in patients with autonomous cortisol secretion and patients with the nonfunctional adrenal masses

Authors : Ferhat Can PİŞKİN, Fulya ODABAŞ, Ulcaz Perihan AKSOYDAN, Gamze AKKUŞ

Pages : 911-918

Doi:10.17826/cumj.1319639

View : 25 | Download : 46

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Purpose: This study aimed to explore the impact of continuous autonomous cortisol secretion on visceral insert ignore into journalissuearticles values(VAT);, abdominal subcutaneous insert ignore into journalissuearticles values(SAT); adipose tissue, and total body fat. Materials and Methods: A total of 57 patients insert ignore into journalissuearticles values(36 female, 21 male); with adrenal masses, referred to our single center, were included in this study. Among them, 31 patients had adrenal cortical carcinoma insert ignore into journalissuearticles values(ACS); and 26 had nonfunctional adrenal mass insert ignore into journalissuearticles values(NFAM);. Hormonal evaluation was conducted for all patients. Measurements of total, visceral, and subcutaneous adipose tissue were performed using 3.0 T magnetic resonance imaging insert ignore into journalissuearticles values(Ingenia, Philips Medical Systems, Best, The Netherlands);. Results: Mean age, gender distribution, and body mass index insert ignore into journalissuearticles values(BMI); were comparable between patients with ACS and NFAM. Patients with ACS exhibited higher volumes of both total insert ignore into journalissuearticles values(422.1±131.3 vs. 346.2±86.0 cm3); and visceral adipose tissue insert ignore into journalissuearticles values(199.9±77.3 vs. 160.6±60.8 cm3); compared to those with NFAM. Incidence rates of diabetes mellitus and hepatosteatosis were similar in both groups. Subcutaneous adipose tissue volumes, visceral-to-subcutaneous ratio, and visceral-to-total fat ratio showed no significant differences between the two groups. Conclusion: Patients with ACS demonstrated increased total and visceral fat tissue volumes compared to NFAM patients matched for gender, age, and BMI. This observation may elucidate the potential influence of continuous mild autonomous cortisol secretion in ACS patients. Such findings could serve as indicators of heightened cardiovascular risk among ACS patients.
Keywords : Otonom kortizol sekresyonu, fonksiyonel olmayan adrenal kitleleri, viseral yağ dokusu, manyetik rezonans görüntüleme