EZH2 expression in the skin of developing human fetuses and adults: a comparative study

Authors : Özge ZORLU, Sevil KARABAĞ, Kivilcim ERDOGAN, Evin KUŞSEVER, İlke ÖZER ASLAN

Pages : 1081-1089

Doi:10.17826/cumj.1321745

View : 17 | Download : 30

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Purpose: In animals, the appropriate levels of Enhancer of zeste homolog 2 insert ignore into journalissuearticles values(EZH2);, a well-established epigenetic regulator, are essential for the embryonic development of skin and appendages. We aimed to explore the EZH2 expression patterns in the skin of human fetuses and compare them with adults. Materials and Methods: We performed EZH2 immunohistochemical staining in skin samples from the scalp region of 67 fetuses and from the farthest surgical margin of the lip wedge resection, where no lesions were found, of 23 adults. EZH2 scores were evaluated according to the literature. Results: Epidermal insert ignore into journalissuearticles values(r = − 0.528);, dermal insert ignore into journalissuearticles values(rs = − 0.509);, and hair follicle insert ignore into journalissuearticles values(r = − 0.576); EZH2 scores were inversely correlated with gestational age. Epidermal and hair follicle EZH2 scores were significantly higher in adults compared to fetuses. There were significant and positive correlations between epidermal, dermal, and hair follicle EZH2 scores among fetuses and adults. Conclusion: Lower levels of EZH2 may be necessary for final cutaneous differentiation and maturation before birth. Our findings may have a therapeutic impact on cutaneous disorders with differentiation defects, chronic wounds, and alopecias.
Keywords : Fetüs, EZH2, deri, epidermis, dermis, kıl folikülü