Insulin resistance and cardiovascular risk factors in childhood metabolic dysfunction-associated steatotic liver disease

Authors : Meltem GÜMÜŞ, Alaaddin YORULMAZ, Hakan CANDAN, Anna Carina ERGANİ, Reyhan GÜMÜŞTEKİN, Fuat BUĞRUL, Hüsamettin VATANSEV, Halil Haldun EMİROĞLU

Pages : 1115-1130

Doi:10.17826/cumj.1326206

View : 18 | Download : 39

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Purpose: The objectives of the present study were to develop biochemical indices as a more practical way for the early diagnosis of cases with suspected metabolic dysfunction-assosiated steatotic liver disease insert ignore into journalissuearticles values(MASLD); and to develop easy biomarkers to enable clinicians to recognize MASLD in obese children. Materials and Methods: A total of 90 patients who had MASLD and 70 healthy volunteering children between the ages of 6-18 who were diagnosed with reference to the ESPGHAN 2012 Guideline between January 2020 and March 2023 were included. Age, gender, Anthropometric measurements and biochemical analysis were determined. Some Biochemical ratios such as HOMA-IR, HOMA-β, FGIR, QUICKI, AIP etc were calculated. Results: There were 40 insert ignore into journalissuearticles values(44.4%); girls and 50 insert ignore into journalissuearticles values(55.6%); boys in the patient group.A positive correlation was found between AST, GGT, TSH, LDL, TG, total cholesterol, HDL, FAS, insulin, HOMA-IR, HOMA-β, QUICKI score, FGIR, MHR, LHR, LKR, THR ALT/AST ratios and Systemic Immun Inflammatory Index values in the analysis. The ROC analysis results of the HOMA-IR value was taken as 2.94, the specificity of the diagnostic value was found to be 52.20% and the sensitivity was 80.0%. Conclusion: MASLD has an increasing trend today.Based on the design of the present study, it was concluded that almost all of the biochemical parameters and biomarkers obtained are among the most accurate and useful indices to determine MASLD and IR and predict complications.
Keywords : Metabolik Disfonksiyonla İlişkili Yağlı Karaciğer Hastalığı, Bİyobelirteç, Çocuk