CHEMOMETRIC ANALYSIS OF MOXIFLOXACIN AND METRONIDAZOLE IN BINARY DRUG COMBINATIONS WITH SPECTROPHOTOMETRIC METHOD

Authors : Güzide Pekcan Ertokuş, ÜMİT MURAT ÇELİK

Pages : 30-37

View : 15 | Download : 7

Publication Date : 2017-11-30

Article Type : Research Paper

Abstract :  In this study, sensitive and accurate spectrophotometric-chemometric methods were developed for metronidazole and moxifloxacin without any separation step in pharmaceutical tablets. The examined Alzheimer`s drugs are donepezil and rivastigmine. The used chemometric methods are partial least squares regression insert ignore into journalissuearticles values(PLS); and principal component regression insert ignore into journalissuearticles values(PCR);. PLS and PCR were successfully applied for chemometric analysis of metronidazole and moxifloxacin in synthetic mixtures and pharmaceutical tablets. A concentration set including binary mixtures of metronidazole and moxifloxacin formed to 24 different combinations were randomly prepared in 0.1 M HCl. The accuracy and precision of the developed method were validated by analyzing synthetic mixtures containing the examined drugs. As a result of the determination, high recoveries and low standard deviations were found. Absorbance and concentration values were used in Minitab and other chemometric programs to calculate estimated concentrations with PCR and PLS.  The second step, in drug tablets insert ignore into journalissuearticles values(Avelox and Flagy);, was calculated amounts for metronidazole and moxifloxacin .
Keywords : Metronidazole and moxifloxacin, PLS