Development of effervescent tablet formulation which contain ferrous salt and ascorbic acid combination

Authors : Hasip Cem OZYURT, Reza MEHRAD

Pages : 35-49

View : 15 | Download : 8

Publication Date : 2020-03-29

Article Type : Research Paper

Abstract :This study aimed to develop the formulation of effervescent tablets containing ferrous sulfate and ascorbic acid combination to increase intestinal iron absorption and reduce gastrointestinal side effects related to iron supplementation. In this study, the prototype formulation was calculated precisely and then prepared by three different methods for compression and evaluation. The flowability of powders and granules was investigated. Effervescent tablets were produced by direct compression and two different wet granulation methods. The produced tablets were then evaluated for acceptable hardness, friability <1 %, effervescence time <5 minutes, solution pH <6, water content <0.5 %, and optimum content uniformity. The powder mixture prepared for the direct compression method had acceptable flowability but required a high compression force. Flowability and other physicochemical properties of this powder, including compressibility and hardness, were improved by granulation. The taste and color of the effervescent solution had good acceptability for the volunteers. The results of the effervescent tablets produced by the GM2 method, which contain a higher percentage of granulated content were better than the other two methods. The PVP binder solution is suitable to produce effervescent granules that are compressed into tablets, due to improvements in flowability and compactibility.
Keywords : effervescent tablet, ferrous sulfate, direct compression method, wet granulation method