PHYTOEQUIVALENCY OF GINKGO BILOBA PRODUCTS: PHARMACOPOEIAL METHOD

Authors : Haleh PİRİ, Beste ATLİ, Nesrin OZTİNEN, Ezgi AK-SAKALLİ, Muberra KOSAR

Pages : 1-9

View : 17 | Download : 6

Publication Date : 2021-07-04

Article Type : Research Paper

Abstract :Ginkgo biloba L., maidenhair tree, is the only living species in the Ginkgophyta division. Standardized G. biloba extracts is used within the pharmaceutical preparations for the treatment of Alzheimer`s and Parkinson’s diseases, as well as vascular dementia, vascular tinnitus, and toxicological properties. Plant extract contains three different active chemical classes: Flavonoids insert ignore into journalissuearticles values(kaempferol, meletin, isorhamnetin, etc.);, terpenoids insert ignore into journalissuearticles values(ginkgolides A, B, and C);, and ginkgolic acid. In this study, the commercial preparations obtained from the pharmacy were analysed and compared with standard medicine according to their chemical compositions. Chemical analyses were performed by reverse phase High Performance Liquid Chromatography insert ignore into journalissuearticles values(HPLC);. Seven commercial products were analyzed and compared with standardized extract contained medicine Tebokan® insert ignore into journalissuearticles values(Abdi Ibrahim, Turkey); by HPLC. While none of the commercial product was found to be equal to the Tebokan®, only one product was investigated similarly according to the important chemical compounds. Quercetin and Isorhamnetin were evaluated in all samples and the standard as well.
Keywords : Ginkgo biloba, HPLC, quercetin, isorhamnetin