DETERMINATION AND EVALUATION OF ACIDITY CONSTANTS OF SOME IMIDAZOLE AND THIAZOLE LINKED ACETAMIDE COMPOUNDS

Authors : Funda TAY, Murat DURAN, Cihan İSPİR, Şeref DEMİRAYAK

Pages : 263-272

Doi:10.18038/btda.96904

View : 14 | Download : 7

Publication Date : 2016-07-14

Article Type : Research Paper

Abstract :In this work, the effect of substituents on the acidity constants of some acetamide derivatives was investigated. The acidity constants of nine acetamide derivatives were determined at 25 °C using a UV spectrophotometric method. When the molecules possessed different substituents the values of the acidity constants changed from 6.01 to 8.22 for the first protonation and from 3.07 to 4.73 for the second protonation. The first protonation under these circumstances was observed to occur on the nitrogen atom of the 2-mercaptoimidazole ring. The second protonation was observed to occur on the nitrogen atom of the thiazole ring.
Keywords : İmidazol, Tiyazol, Asetamit, Protonlanma yolları, UV spektroskopi, pKa