Synthesis of chitosan-based hydrogel by using photopolymerization technique

Authors : Neslihan ALEMDAR

Pages : 391-400

Doi:10.18038/btda.96384

View : 12 | Download : 8

Publication Date : 2016-07-14

Article Type : Research Paper

Abstract :In this study, a novel route was developed to fabricate chitosan-based hydrogels by using photopolymerization technique. For this, firstly, glycidyl methacrylate insert ignore into journalissuearticles values(GMA); grafted onto the chitosan insert ignore into journalissuearticles values(CTS); backbone to produce chitosan derivative product having photopolymerizable groups  insert ignore into journalissuearticles values(CTS-g-GMA);. Following, CTS-g-GMA and PEGDA subjected to photopolymerization to form chemically crosslinked hydrogel. The chemical structure of the obtained chitosan-based hydrogel was characterized by Fourier transform infrared insert ignore into journalissuearticles values(FT-IR); analyses. Thermal behavior of hydrogel was determined by differential thermal analysis insert ignore into journalissuearticles values(DTA); and thermal gravimetric analysis insert ignore into journalissuearticles values(TGA);. The thermal analyses showed that insert ignore into journalissuearticles values(CTS-g-GMA);-PEGDA had higher thermal stability than neat chitosan. Additionally, the water uptake capacities insert ignore into journalissuearticles values(swelling ratio); of hydrogels obtained by using different UV exposure time were determined gravimetrically. From the swelling test result, it was observed that exposure time has the effect on the water uptake capacity of hydrogels. In the light of the obtained results, chitosan-based hydrogel fabricated in this work could be considered as a potential for biomedical applications in future works. 
Keywords : Chitosan, Photopolymerization, Polymeric network, Hydrogel