entrCYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINESCYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON LEUKEMIA CELL LINES

Authors : Hakan ÜNVER, Zerrin CANTÜRK

Pages : 628-636

View : 12 | Download : 7

Publication Date : 2018-09-01

Article Type : Research Paper

Abstract :Ferulic acid insert ignore into journalissuearticles values(FA);, or 4-hydroxy-3-methoxycinnamic acid, is a phenolic compound that can be used in many pharmacological applications, especially in the area of cancer. In this study, four new FA-quinoline esters were successfully synthesized and characterized using 1H-NMR, 13C-NMR, HR-Mass, Elemental Analysis, and FT-IR techniques. Synthesized compounds were tested on leukemia cell lines insert ignore into journalissuearticles values(HL-60 and K562); with WST-1 assay and Annexin V-PI assay via flow cytometry. The WST-1 assay of compounds in HL-60 and K562 leukemia cells yielded IC50 124.4 and 205.4 μM/mL, respectively. According to the results, both the cytotoxic effect and apoptotic effects of 2c increased on HL-60 cell.
Keywords : Ferulic Acid, Leukemia, Apoptosis, Cytotoxicity