PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS

Authors : Fatih Erdem BAŞTAN

Pages : 10-22

Doi:10.18038/estubtda.674424

View : 12 | Download : 7

Publication Date : 2021-03-26

Article Type : Research Paper

Abstract :In this study, it is aimed to produce composite hydroxyapatite insert ignore into journalissuearticles values(HA); gelatin microspheres insert ignore into journalissuearticles values(HA-Gel); intended for drug delivery applications. The polymer network within the HA particle-matrix can be facilitated as a drug carrier system. The dissolution of the polymer in the physiological medium allows to release the drug in a controlled manner and also develop the cell-microsphere interactions. Gelatin functionalized HA microspheres and bare HA granules were produced by spray drying. The morphology, thermal properties, chemical and phase structure of the produced powders were analysed with SEM, TG-DTA, FTIR and XRD. HA-Gel microspheres presented spherical morphology and hollow/core-shell cross-section and included HA nanoparticles and gelatin together according to the SEM, FTIR and XRD studies. TG-DTA results showed that gelatin was evolved from the microspheres ~300 °C, and bare HA was stable up to 1400 °C. Gelatin was released from the microspheres after immersion in the phosphate buffer saline insert ignore into journalissuearticles values(PBS); solution for 14 days.
Keywords : Functionalized Hydroxyapatite, gelatin, spray drying