Haemoglobin E Distribution in Four Endogamous Populations of Manipur (India)

Authors : Maishnam Rustam SİNGH, Bapukan CHOUDHURY, T. Shyamacharan SİNGH

Pages : 109-117

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Publication Date : 2010-12-30

Article Type : Research Paper

Abstract :The present paper is a report on the prevalence of Haemoglobin E insert ignore into journalissuearticles values(HbE); among four endogamous populations of Manipur insert ignore into journalissuearticles values(India); namely the Kabui, Koireng, Simte and the Meitei. The average allele frequency of HbβE observed among the Meitei is 0.101. However, the frequency of HbβE ranges from 0.045 to 0.226 among various sections of the Meitei. The frequency of HbβE among the Phayeng Chakpa shows the highest value insert ignore into journalissuearticles values(0.226); while the Ningthoukhong Meitei shows the lowest insert ignore into journalissuearticles values(0.045);. The frequency of HbβE among the hill Kabui population is 0.035 followed by the Koireng insert ignore into journalissuearticles values(0.029); and the Simte insert ignore into journalissuearticles values(0.012);. The frequency of HbβE among the various tribal populations of malaria endemic zones of Manipur is below 0.04. It is indicative that the ethnic origin and marriage system may be the responsible factors for variation in the frequencies of HbE gene among the populations of Manipur. In the present study, neither protective advantage of HbβE against malaria nor harmful effect of homozygous insert ignore into journalissuearticles values(HbEE); genotype could be satisfactorily established.
Keywords : Haemoglobin E, malaria, endogamous, populations of Manipur