SYNTHESIS AND RADICAL SCAVENGING PROPERTIES OF SELENOPHENYL BENZAMIDE ANOLOGS

Authors : Aliye Altundas, Kadir Doğanay, Merve Göksin Karaaslan, Burhan Ates

Pages : 317-321

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Publication Date : 2016-06-20

Article Type : Conference Paper

Abstract :Free radicals that result from different kinds of oxidative stress have been concerned in a variety of human disorders, from cardiac ischemia to those affecting the central nervous system. So, there is an increasing interest in the development of antioxidant molecules that can protect cells against free radical damages. Sets of tetrasubstituted selenophene amides 4a-e were synthesized by reaction of 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]selenophen-3-carbonitrile insert ignore into journalissuearticles values( 2); with benzoyl chloride derivatives and the structures of the amide derivatives were characterized by MS, 1 H-NMR, 13 C-NMR and IR spectra. The synthesized compounds insert ignore into journalissuearticles values( 4a-e ); were evaluated in terms of in vitro . The antioxidant properties were determined by 2,2-diphenyl-1-picrylhydrazyl insert ignore into journalissuearticles values(DPPH); radical scavenging properties and IC 50 values of the compounds were in the range from 3.794 to 5.644 mg/mL. Compounds   4c   and   4e   showed predominant radical scavenging activity among the synthesized analogues.
Keywords : Selenophene, Selenopheneyl benzamide, Antioxidant activity