Mutagenicity of 1-Ethyl-2,4,5-triphenyl-1H-imidazole and Six Derivatives in Salmonella typhimurium

Authors : Ferhan KORKMAZ, Ferhan KORKMAZ, Ayse MERCANGOZ

Pages : 1-8

View : 10 | Download : 7

Publication Date : 2012-01-24

Article Type : Research Paper

Abstract :Newly synthesized 1-Ethyl-2,4,5-triphenyl-1H-imidazole and its six derivatives were tested by Ames assay. In order to reveal the mutagenic activities of the compounds, two different mutant strains of Salmonella typhimurium insert ignore into journalissuearticles values(TA98 and TA100); were used in an Ames assay with/without S9 microsomal fraction from rat liver. It was found that the compounds have no mutagenic activities.
Keywords : 1 Ethyl 2, 4, 5 triphenyl 1H imidazole, Ames Salmonella Microsome assay, mutagenicity, predrug