Investigation of Chloride Anion Binding Properties of Glipizide Drug

Authors : Serap MERT

Pages : 262-277

Doi:10.54287/gujsa.1281246

View : 108 | Download : 79

Publication Date : 2023-09-29

Article Type : Research Paper

Abstract :This study addresses the anion binding property of Glipizide insert ignore into journalissuearticles values(GLP);, an oral antidiabetic a second-generation drug member of the sulphonylurea insert ignore into journalissuearticles values(SU); family. GLP effectively interacts with Cl- anion according to 1H-NMR spectroscopic titrations of successive tetrabutylammonium chloride insert ignore into journalissuearticles values(TBACl); in deuterated chloroform insert ignore into journalissuearticles values(CDCl3); and dimethyl sulfoxide insert ignore into journalissuearticles values(d6-DMSO);. Upon the addition of TBACl, the change in chemical shift was observed for both N-H protons of SU in CDCl3, whereas it causes a difference in the shift of only one of N-H proton in SU in d6-DMSO. In addition, the data obtained from 1H-NMR spectroscopic titrations was analyzed by DynaFit program to calculate the binding constant insert ignore into journalissuearticles values(Ka); value between GLP and Cl- anion. It was found that GLP binds Cl- anion in CDCl3 with higher affinity insert ignore into journalissuearticles values(Ka=77.37 M-1, Fitplot for N-Hh proton at δ=6.47 ppm); than in d6-DMSO insert ignore into journalissuearticles values(Ka=38.53 M-1, Fitplot for N-Hh proton at δ=6.32 ppm);.
Keywords : Anion Receptor, Sulphonylurea, Glipizide, 1H NMR Titration