Evaluation of controlled hydroxychloroquine releasing performance from calcium-alginate beads

Authors : Canan ARMUTCU, Sena PİŞKİN

Pages : 255-263

Doi:10.17350/HJSE19030000236

View : 10 | Download : 8

Publication Date : 2021-09-29

Article Type : Research Paper

Abstract :The aim of this study was to develop an effective controlled drug delivery system based on alginate beads for the treatment of autoimmune diseases such as Rheumatoid Arthritis insert ignore into journalissuearticles values(RA); and Systemic Lupus Erythematosus insert ignore into journalissuearticles values(SLE);. The present study describes the drug delivery systems to control the effective uses of hydroxychloroquine insert ignore into journalissuearticles values(HCQ); by Ca-alginate beads. The characterization techniques were employed to evaluate the physicochemical properties as scanning electron microscopy insert ignore into journalissuearticles values(SEM);, swelling test insert ignore into journalissuearticles values(S);, hydrolytic degradation insert ignore into journalissuearticles values(weight loss, WL); and Fourier transform infrared-attenuated total reflection insert ignore into journalissuearticles values(FTIR-ATR);. The release studies from alginate beads prepared in various drug dose were carried out in the aqueous solutions at different pH insert ignore into journalissuearticles values(5–8); and temperature insert ignore into journalissuearticles values(4-37oC);. The approximately half-amount of HCQ in HCQ-AB3 was released in 12 h and about 84.38% was released within 8 days. Kinetic model, Korsmeyer-Peppas was applied to model the HCQ release kinetic of alginate beads, which corresponded to non-Fickian transport mechanism.
Keywords : Calcium alginate beads, hydroxychloroquine, drug delivery, RA, SLE