Synthesis, Characterization, Anti-bacterial and Anti-inflammatory Activities of Bismuth(III) Complexes Based on 5-chloro-2-mercaptobenzothiazole

Authors : İbrahim İsmet ÖZTÜRK, Muazzez GÜRGAN ESER

Pages : 225-233

Doi:10.17350/HJSE19030000275

View : 14 | Download : 7

Publication Date : 2022-09-28

Article Type : Research Paper

Abstract :Bismuth, known as a heavy metal, is excluded from this class due to its low toxicity. Due to this feature, bismuth containing compounds have always been interesting compounds in the field of medicinal chemistry. For this reason, the discovery of new bismuth compounds and the investigation of their biological properties are very important for this field. In this study, three new bismuthinsert ignore into journalissuearticles values(III); compounds formulated as [Biinsert ignore into journalissuearticles values(L);2X3] insert ignore into journalissuearticles values(L: 5-chloro-2-mercaptobenzothiazole insert ignore into journalissuearticles values(ClMBZT);; X: Cl, Br, and I); were synthesized for the first time and, the molecular structure of them were elucidated by a series of spectroscopic techniques. Thermal stability and degradation steps of the title compounds were analyzed by Thermogravimetric-Differential Thermal Analysis insert ignore into journalissuearticles values(TG-DTA);. The antibacterial study has been conducted against six strains bacteria, and the results indicated that bismuthinsert ignore into journalissuearticles values(III); compounds generally showed more effective antibacterial activity than free ligand. The anti-inflammatory potential of bismuthinsert ignore into journalissuearticles values(III); compounds was investigated through in vitro lipoxygenase enzyme inhibition studies. The results show that bismuthinsert ignore into journalissuearticles values(III); compounds have higher anti-inflammatory potential than free ligand.
Keywords : Bismuth III, compounds, Spectroscopic techniques, Antibacterial activity, Anti inflammatory potential