Anti-Proliferative Effect of Rosa Agrestis on Endometrium Cancer Cells In Vitro

Authors : Mine ERGÜVEN, Sükran KÜLTÜR, Nurten ÖZSOY

Pages : 17-23

Doi:10.17932/ IAU.IJFER.m.21495777.2015.1/1.17-23

View : 20 | Download : 8

Publication Date : 2015-06-01

Article Type : Research Paper

Abstract :Endometrial cancer is the most common gynaecological malignant disease. Despite of some arguments about the preference of herbal medicine to pharmaceutical drugs, because of their minimal side effects herbal medicine is proven to be effective as a single application and/or an adjuvant therapy. Rosa agretis Savi R. agretis Savi which belongs to Rosaceae family has been used traditionally to treat allergy, antiatopic dermatitis, and some inflammatory diseases, is commonly studied. Anti-oxidant activity is also reported. The present study was undertaken to investigate the in vitro anticancer activity of R. agrestis parts leaves, flowers at endometrium cancer. Extracts in a concentration of 1 µg/ml to 200 µg/ml from leaves and flowers were tested on human endometrium cell line named Ischikawa for 72 h. Cell proliferation total cell number and apoptotic index flow cytometry were evaluated for 72 h. All the results were statistically analyzed using the independent Student’s t-test. All extracts decreased cell number and increased apoptotic index with dead cells in concentration and time dependent manner p
Keywords : Rosa agrestis Savi, endometrium cancer, anticancer activity